Scientific Articles
Functional Performance, Subject-Body Perception, and Safety Following Multi-Muscle Electromuscular Stimulation: A Randomized Controlled Study
- Author:
- Kiya Movassaghi, MD, DMD, FACS; Niloo Marashi, MS; Shlomit Mann, MSc; Ruthie Amir, MD
- Publication:
- Aesthetic Surgery Journal — Oxford University Press / The Aesthetic Society
- Date:
- Aug 2026
Summary
This prospective, randomized, blank-controlled study evaluated functional performance, subject-body perception, and safety following treatment with PlyoPulse™ electromuscular stimulation delivered through the Pure Impact™ VIP platform. Thirty-eight healthy adults were randomized equally to treatment or untreated control groups. Treated subjects received six weekly sessions targeting the abdomen, quadriceps, hamstrings, and glutes. At week 5, the treatment group showed statistically significant improvement across all four objective functional tests, including hip extension, curl-up performance, quadriceps extension, and side-plank endurance. Most gains were sustained four weeks after the final treatment. Body-Q® scores also improved, and treatment was well tolerated with low discomfort and no adverse events reported.
Topics Covered
- Randomized controlled study of PlyoPulse™ EMS
- Objective gains across four functional performance tests
- Improved body perception and perceived muscle strength
- Low discomfort and no adverse events reported
Integrating dermal and muscular regeneration: the clinical role of Sofwave and Pure Impact VIP in modern aesthetics
- Author:
- Dr Jennifer Doyle, Aesthetic Doctor and Consultant Oculoplastic Surgeon; Dr Arshi Baig, Aesthetic Doctor and Ophthalmology Registrar
- Publication:
- Journal of Aesthetic Nursing, Volume 15, Issue 3
- Date:
- Jul 2026
Summary
This double-blind peer-reviewed clinical review examines the complementary roles of Sofwave and Pure Impact VIP in modern regenerative aesthetics, with particular attention to patients experiencing skin laxity, tissue deflation, and muscle depletion after ageing or significant GLP-1-associated weight loss. Sofwave uses Synchronous Ultrasound Parallel Beam (SUPERB™) technology to create controlled thermal coagulation zones at approximately 1.5 mm in the mid-dermis, stimulating fibroblast activity, neocollagenesis and neoelastogenesis while preserving the epidermis, deeper fat and SMAS. The review summarizes evidence supporting improvements in mild-to-moderate skin laxity, facial lines and wrinkles, brow lifting, submental and neck laxity, upper-arm laxity and acne scarring, generally with minimal downtime and a favorable safety profile. Pure Impact VIP is presented as a fourth-generation electrical muscle stimulation platform using PlyoPulse technology to induce supramaximal contractions across multiple muscle groups. The authors describe its potential to improve muscle recruitment, tone, firmness and structural support, including simultaneous treatment of several anatomical regions.
Topics Covered
- SUPERB ultrasound for mid-dermal collagen remodeling
- Pure Impact VIP muscle conditioning technology
- Regenerative aesthetics after GLP-1 weight loss
- Sofwave clinical evidence and FDA indications
- Comparison with HIFU and RF microneedling
- Laser resurfacing versus ultrasound skin lifting
- Patient selection, protocols and treatment safety
- Multimodal dermal and muscular regeneration strategies
A Single-Center, Blinded, Split-Body, Randomized Clinical Trial of High-Intensity, Parallel Ultrasound Beams Versus Microfocused Ultrasound With Visualization for the Treatment of Upper Inner Arm Skin Laxity
- Author:
- Jameson Loyal, MD; Nina Hartman, MD; Mitchel P. Goldman, MD
- Publication:
- Dermatologic Surgery - American Society for Dermatologic Surgery / Wolters Kluwer
- Date:
- Apr 2026
Summary
This blinded, randomized split-body clinical trial directly compared high-intensity parallel ultrasound with microfocused ultrasound with visualization for upper inner-arm skin laxity and crepiness. Fourteen female subjects completed the study, receiving one modality on each arm so that every participant served as her own control. Investigator and subject assessments at days 30 and 90 showed improvement with both technologies, and the parallel-ultrasound treatment was found to be similarly effective for laxity and crepiness. Pain scores did not differ significantly between treatments. A practical difference was treatment duration: microfocused ultrasound with visualization required more time to perform. The study therefore suggests that high-intensity parallel ultrasound can provide comparable clinical improvement with high patient satisfaction while offering a faster treatment procedure.
Topics Covered
- Randomized split-body upper-arm lifting comparison
- Parallel ultrasound versus microfocused ultrasound visualization
- Comparable laxity and crepiness improvement outcomes
- Shorter treatment time with parallel ultrasound
The Efficacy and Safety of Synchronous Parallel Ultrasound for the Clinical Improvement of Cellulite Using High-Density Handpiece
- Author:
- Michael H. Gold; Eric F. Bernstein; Anne M. Chapas; Suzanne L. Kilmer; Oleg Bedich; Ruthie Amir; David J. Goldberg
- Publication:
- Journal of Cosmetic Dermatology - Wiley Periodicals LLC
- Date:
- Dec 2025
Summary
This prospective, open-label multicenter study evaluated synchronous parallel ultrasound delivered with a new high-density handpiece for improving cellulite of the thighs and buttocks. Sixty subjects aged 23 to 65 received two treatment sessions, and outcomes were assessed up to three months after the second treatment. Blinded physician evaluations found improvement on the Global Aesthetic Improvement Scale in 91% of treated areas. Cellulite Severity Scale scores improved by 69%, while laxity scores improved by 53%. Seventy-three percent of subjects reported satisfaction, and the mean discomfort score was 4.26. No serious adverse events were reported. The study indicates that the high-density handpiece can safely improve both the dimpled appearance of cellulite and associated skin laxity.
Topics Covered
- High-density handpiece for cellulite improvement
- Thigh and buttock synchronous ultrasound treatment
- Cellulite severity and skin laxity reduction
- Multicenter safety satisfaction and efficacy outcomes
The Efficacy and Safety of Combining Cross-Linked Hyaluronic Acid Filler VYC-12L and Energy-Based Devices for Facial Skin Quality Improvement in Asians
- Author:
- Mikako Oku; Kentaro Oku
- Publication:
- Journal of Cosmetic Dermatology - Wiley Periodicals LLC
- Date:
- Oct 2025
Summary
This prospective evaluator-blinded study examined a combination strategy using cross-linked hyaluronic acid filler VYC-12L followed by an energy-based device selected according to each patient's primary skin concerns. Eighteen Asian participants received full-face filler treatment, then one month later underwent an energy-based procedure that could include high-intensity, high-frequency parallel ultrasound, picosecond laser, or sequential radiofrequency. Patient-reported FACE-Q skin satisfaction scores improved significantly over time, and objective Global Aesthetic Improvement Scale assessments showed improvement in every participant. Three-dimensional and diagnostic skin imaging were also used to evaluate outcomes. No severe adverse events occurred; only minor transient reactions were observed. The study supports individualized combination therapy for improving multiple dimensions of facial skin quality rather than relying on a single modality.
Topics Covered
- Combination filler and energy-based facial therapy
- Asian facial skin quality improvement outcomes
- Parallel ultrasound within personalized treatment plans
- Patient satisfaction and objective aesthetic improvement
A Single-Center Study to Evaluate the Safety, Efficacy, and Patient Satisfaction Associated With High-Intensity Ultrasound Treatment for Skin Crepiness/Laxity
- Author:
- Maya Firsowicz, MD, FAAD; Payvand Kamrani, DO, FAAD; Kavita Darji, MD, FAAD; Misha Zarbafian, MD, FAAD; Mitchel P. Goldman, MD, FAAD
- Publication:
- Dermatologic Surgery - American Society for Dermatologic Surgery / Wolters Kluwer
- Date:
- Sep 2025
Summary
This single-center retrospective study evaluated the safety, efficacy, and patient satisfaction associated with high-intensity ultrasound treatment for facial skin crepiness and laxity. Clinical records and standardized assessments were reviewed to determine both physician-observed improvement and the patients' own perception of treatment benefit. Most patients reported visible improvement after treatment, and physician evaluations similarly documented aesthetic gains in laxity and skin quality. Patient satisfaction was high, suggesting that the clinical changes were meaningful from the patient's perspective as well as observable by clinicians. Overall, the study adds real-world clinical evidence that high-intensity ultrasound can provide a noninvasive option for improving facial laxity and crepey skin with limited treatment-related morbidity.
Topics Covered
- High-intensity ultrasound for facial skin laxity
- Patient satisfaction after noninvasive lifting treatment
- Physician and patient global improvement assessments
- Minimal side effects with visible improvement
Synchronous Parallel Ultrasound Induces Long-Term Extracellular Matrix Remodeling of Human Skin
- Author:
- Jean Carruthers, MD; Virginia Benitez Roig, MD; David H. McDaniel, MD, FAAD; Brooke Jackson, MD, FAAD; Oleg Bedich, MSc; Ruthie Amir, MD; Shimon Eckhouse, PhD
- Publication:
- Dermatologic Surgery - American Society for Dermatologic Surgery / Wolters Kluwer
- Date:
- Sep 2025
Summary
This translational study investigated how synchronous parallel ultrasound affects the extracellular matrix over both short and long time periods. The researchers examined tissue responses in porcine models and in human skin biopsies, allowing them to evaluate structural changes rather than relying solely on visible aesthetic outcomes. Human biopsy findings extending to 10 months after treatment demonstrated sustained increases and reorganization of collagen and elastin fibers. The study also reported increased glycosaminoglycans, a finding consistent with ongoing fibroblast activity and extracellular matrix regeneration. Together, these results suggest that the biological response to parallel ultrasound continues well beyond the initial thermal effect and may support durable clinical improvement. The work provides histologic evidence for long-term dermal remodeling after synchronous parallel ultrasound treatment.
High-Intensity, High-Frequency, Parallel Ultrasound Beam Device for Skin Laxity of the Upper Arms
- Author:
- Jordan V. Wang, MD, MBE, MBA; Neil Jairath, MD; Shirin Bajaj, MD; Amy Taub, MD; Eric Bernstein, MD; Roy G. Geronemus, MD; Suzanne Kilmer, MD
- Publication:
- Dermatologic Surgery - American Society for Dermatologic Surgery / Wolters Kluwer
- Date:
- Sep 2025
Summary
This prospective multicenter study assessed high-intensity, high-frequency parallel ultrasound beams for treating crepiness and skin laxity of the upper arms. Forty-six subjects received two treatment sessions and were evaluated at follow-up using standardized photography and blinded aesthetic assessments. At three months, reviewers documented significant improvement in both crepiness and laxity, and 93.3% of evaluated photographs were rated as improved on the Global Aesthetic Improvement Scale. The treatment targets dermal tissue with controlled ultrasound-generated thermal zones intended to stimulate collagen contraction and longer-term remodeling without surgery. No device-related adverse events were reported. The findings extend the clinical use of parallel ultrasound beyond the face and neck and support its potential for noninvasive treatment of difficult off-face laxity.
Topics Covered
- Upper-arm laxity and crepiness treatment
- Two-treatment prospective multicenter clinical study
- Blinded assessment of aesthetic arm improvement
- Noninvasive dermal remodeling with parallel ultrasound
High-Intensity, High-Frequency, Parallel Ultrasound Beams for Facial Acne Scars
- Author:
- Jordan V. Wang, MD, MBE, MBA; Nkem Ugonabo, MD; Lauren Hoffman, MD; Shirin Bajaj, MD; Megan O’Donnell, MD; Anne Chapas, MD; David Goldberg, MD; Roy G. Geronemus, MD; Arielle Kauvar, MD
- Publication:
- Dermatologic Surgery - American Society for Dermatologic Surgery / Wolters Kluwer
- Date:
- Aug 2025
Summary
This prospective multicenter study investigated high-intensity, high-frequency parallel ultrasound beams as a treatment for facial acne scars. Subjects could receive up to three treatment sessions, and outcomes were evaluated through standardized photography and validated acne-scar severity assessments. Among participants completing at least two treatments, blinded reviewers classified 96.8% as responders. Mean acne-scar severity decreased by approximately 45.5%, indicating a substantial clinical improvement in scar appearance. The treatment uses controlled dermal heating to stimulate collagen remodeling and improve the depressed architecture associated with atrophic scars. No device-related adverse events were reported during the study. The results support parallel ultrasound as a noninvasive or minimally disruptive option for acne-scar improvement, while also providing multicenter evidence beyond earlier preliminary studies.
Topics Covered
- Multicenter treatment of facial acne scars
- Forty-five percent acne scar severity reduction
- Blinded photographic assessment of clinical response
- No device-related adverse events reported
A Systematic Review of High-Intensity Focused Ultrasound in Skin Tightening and Body Contouring
- Author:
- Diala Haykal, MD; Sonja Sattler, MD; Ines Verner, MD; Monisha Madhumita, MD; Hugues Cartier, MD
- Publication:
- Aesthetic Surgery Journal - Oxford University Press / The Aesthetic Society
- Date:
- Jun 2025
Summary
This systematic review evaluated the clinical evidence for high-intensity focused ultrasound in aesthetic skin lifting and body contouring. The authors reviewed 45 clinical trials and cohort studies published between 2010 and October 2024, examining efficacy, safety, patient satisfaction, and emerging technological developments. Across facial and neck applications, reported skin-laxity improvements were generally in the 18%–30% range, while body-contouring studies documented circumference reductions of approximately 2.5–4.5 cm, particularly in the abdomen and thighs. The review also highlights newer parallel-beam ultrasound as an advancement in precision and patient comfort, while emphasizing the need for standardized protocols, optimized energy settings, better patient selection, and longer-term research.
Topics Covered
- Systematic review of aesthetic ultrasound evidence
- Skin lifting and facial regeneration outcomes
- Body contouring and circumference reduction evidence
- Parallel-beam ultrasound as emerging advancement
- Safety protocol standardization and future research
The Efficacy and Safety of a Single Treatment of High-Intensity, High-Frequency, Non-Focused Ultrasound Parallel Beams for Facial Acne Scars in Asian Patients: A Preliminary Study
- Author:
- Kanjana Boonchoo; Wichai Hongcharu
- Publication:
- Journal of Cosmetic Dermatology - Wiley Periodicals LLC
- Date:
- Apr 2025
Summary
This preliminary study evaluated a single treatment with high-intensity, high-frequency non-focused parallel ultrasound beams for atrophic facial acne scars in Asian patients. Fourteen participants received treatment and were followed for up to eight months. Investigators used clinical assessments and three-dimensional imaging to measure changes in scar depression volume over time. The study reported statistically significant reductions in scar volume together with improvement on physician-rated acne-scar assessments, suggesting that dermal thermal stimulation and subsequent collagen remodeling may improve atrophic scar architecture. Importantly, no adverse events were reported during the follow-up period, which is particularly relevant when evaluating energy-based treatments in Asian skin types. The technology is a promising and safe alternative for treating atrophic acne scars.
Topics Covered
- Atrophic acne scar treatment in Asian patients
- Single-session synchronous parallel ultrasound therapy
- Three-dimensional scar depression volume measurement
- Longer follow-up with favorable safety findings
High-Intensity, Parallel Ultrasound Tightening of Facial Skin: Clinical and Pathologic Results
- Author:
- Dong Hye Suh; Sang Jun Lee; Kye Yong Song; Hye-Jin Ahn; Min Kyung Shin
- Publication:
- Journal of Cosmetic Dermatology - Wiley Periodicals LLC
- Date:
- Nov 2024
Summary
This clinical and pathologic study evaluated facial lifting after high-intensity parallel ultrasound and also examined tissue changes through histologic analysis. Thirteen female participants with Fitzpatrick skin types III to V received a single treatment to the entire face and neck. Clinical assessments demonstrated visible lifting, while biopsies showed increased collagen and elastic fibers, particularly within the mid dermis, together with changes in fiber organization after treatment. These findings provide biologic support for the proposed mechanism of ultrasound-induced neocollagenesis and neoelastogenesis rather than relying only on photographic improvement. The treatment creates thermal effects at approximately 1–2 mm depth while preserving the overlying epidermis. The study therefore connects observed aesthetic improvement with measurable structural remodeling of dermal collagen and elastin.
Topics Covered
- Clinical facial lifting with parallel ultrasound
- Histologic evidence of collagen fiber remodeling
- Neoelastogenesis within the treated mid dermis
- Single-treatment face and neck protocol
High-Intensity, High-Frequency, Parallel Ultrasound Beams for Cellulite of the Buttocks and Thighs
- Author:
- Jordan V. Wang, MD, MBE, MBA; Nkem Ugonabo, MD; Shirin Bajaj, MD; Neil Jairath, MD; Girish Munavalli, MD, MHS; Anne Chapas, MD; Roy G. Geronemus, MD; Suzanne Kilmer, MD
- Publication:
- Dermatologic Surgery - American Society for Dermatologic Surgery / Wolters Kluwer
- Date:
- Oct 2024
Summary
This prospective multicenter study evaluated high-intensity, high-frequency parallel ultrasound beams for improving cellulite on the buttocks and thighs. Subjects underwent two treatment sessions, and 65 participants completed the study. Clinical outcomes were assessed with standardized photographs, cellulite severity and laxity scales, and global aesthetic improvement ratings. Investigators found statistically significant reductions in cellulite severity and skin laxity, while 89.2% of treated areas were rated as improved on the Global Aesthetic Improvement Scale. The treatment is intended to remodel dermal tissue through controlled thermal stimulation while preserving the epidermis. No device-related adverse events were reported, and the study included a range of Fitzpatrick skin types. The results support synchronous parallel ultrasound as a noninvasive approach to cellulite and associated laxity.
Topics Covered
- Parallel ultrasound treatment for thigh cellulite
- Buttock cellulite and skin laxity improvement
- Two-treatment multicenter clinical study outcomes
- Safety across Fitzpatrick skin types
Vectorized Facial Skin Tightening: A Study on the Thermal Thread Technique™ Utilizing High-Intensity, High-Frequency, Parallel Ultrasound Beam
- Author:
- Kentaro Oku, MD
- Publication:
- Lasers in Surgery and Medicine - Wiley Periodicals LLC
- Date:
- Feb 2024
Summary
This study introduced the Thermal Thread Technique, a vector-based approach using high-intensity, high-frequency parallel ultrasound beams to direct skin lifting along predetermined facial vectors. Thirty-four subjects received a single treatment designed to create controlled thermal zones oriented in relation to relaxed skin tension lines. Three-dimensional imaging was used to objectively evaluate the magnitude and direction of tissue contraction at eight and 24 weeks. The analysis demonstrated statistically significant and directionally consistent lifting, suggesting that treatment placement can influence the vector of clinical contraction rather than simply producing generalized lifting. Improvements persisted through the later follow-up period, and no treatment-related side effects were reported. The findings support a more strategic, anatomy-guided application of parallel ultrasound for facial regeneration and lifting.
Topics Covered
- Thermal Thread Technique for vectorized lifting
- Directed collagen contraction across facial tension lines
- Three-dimensional measurement of contraction direction
- Single-treatment safety and sustained lifting outcomes
Efficacy and Safety of High-Intensity, High-Frequency, Non-Focused Ultrasound Parallel Beams for Facial Skin Laxity
- Author:
- Michael H. Gold, MD; Julie Biron, BSc
- Publication:
- Journal of Cosmetic Dermatology - Wiley Periodicals LLC
- Date:
- Jan 2024
Summary
This prospective clinical trial evaluated high-intensity, high-frequency, non-focused parallel ultrasound beams for facial skin laxity in the eyebrow, submental, and neck regions. Fifteen subjects aged 40 to 69 received two treatment sessions and were followed for three and six months. Standardized photographs were assessed using physician global aesthetic improvement measures, and improvement was observed across all treated areas at both follow-up visits. The lifting pattern remained stable through the six-month evaluation, suggesting durability beyond the immediate post-treatment period. The mean pain score was 5.6 on a 0–10 scale, indicating tolerable discomfort. The technology safely and efficiently improved lax facial skin, producing eyebrow, submental, and neck lifting through ultrasound-induced dermal remodeling.
Topics Covered
- Facial laxity improvement using non-focused ultrasound
- Eyebrow submental and neck lifting outcomes
- Two-treatment protocol with six-month follow-up
- Tolerable discomfort and favorable safety profile
Ultrasound Therapy for the Skin
- Author:
- Anni Wong, MD; Anne S. Lowery, MD; Jason D. Bloom, MD
- Publication:
- Facial Plastic Surgery Clinics of North America - Elsevier
- Date:
- Nov 2023
Summary
This review discusses the use of ultrasound-based technologies for aesthetic skin treatment, with emphasis on nonsurgical skin lifting and regeneration. It explains how ultrasound energy can create controlled thermal injury at selected tissue depths, triggering collagen contraction and longer-term neocollagenesis and neoelastogenesis while minimizing epidermal damage. The article reviews focused ultrasound approaches as well as newer parallel-beam technology and considers differences in energy delivery, treatment depth, operator dependence, and clinical applications. It also addresses patient selection, expected outcomes, discomfort, safety considerations, and the role of ultrasound in treating facial and neck laxity. Overall, the review presents ultrasound as an increasingly important energy-based modality for patients seeking skin lifting with limited downtime and without surgical intervention.
Topics Covered
- Ultrasound mechanisms for nonsurgical skin regeneration
- Focused and parallel-beam technology differences
- Patient selection for facial skin lifting
- Clinical efficacy safety and treatment considerations
Eyebrow Lifting From High-Intensity, High-Frequency, Parallel Ultrasound Beams
- Author:
- Jordan V. Wang, MD, MBE, MBA; Arielle Kauvar, MD; Roy G. Geronemus, MD
- Publication:
- Dermatologic Surgery - American Society for Dermatologic Surgery / Wolters Kluwer
- Date:
- Jul 2023
Summary
This post-hoc analysis investigated eyebrow lifting after a single full-face and neck treatment using high-intensity, high-frequency parallel ultrasound beams. Investigators compared standardized baseline and follow-up photographs and objectively measured changes in eyebrow height. All subjects included in the analysis met the prespecified responder threshold, and the average eyebrow-height increase was approximately 1.4 mm. Investigator assessments and patient feedback also supported visible aesthetic improvement. The treatment delivers controlled thermal energy into the dermis, promoting collagen contraction followed by neocollagenesis and remodeling, which can produce a subtle lifting effect without surgery. No device-related adverse events were reported. The study therefore provides quantitative evidence that parallel ultrasound can contribute to noninvasive upper-face and eyebrow lifting.
Topics Covered
- Noninvasive eyebrow lifting after single treatment
- Objective measurement of eyebrow height changes
- Patient satisfaction and investigator aesthetic improvement
- Neocollagenesis supporting upper-face skin lifting
High-Intensity, High-Frequency, Parallel Ultrasound Beams for Submental Lifting
- Author:
- Jordan V. Wang, MD, MBE, MBA; Roy G. Geronemus, MD; Arielle Kauvar, MD
- Publication:
- Dermatologic Surgery - American Society for Dermatologic Surgery / Wolters Kluwer
- Date:
- May 2023
Summary
This analysis examined whether a single treatment with high-intensity, high-frequency parallel ultrasound beams could produce measurable lifting in the submental region. Using standardized clinical photographs from a pivotal facial regeneration study, investigators performed quantitative image analysis to compare baseline and 12-week follow-up images. The results demonstrated statistically significant lifting of the submental area, supporting the ability of synchronous parallel ultrasound to lift lax skin without surgery. The proposed mechanism is controlled dermal heating, which causes collagen contraction and subsequently stimulates neocollagenesis and tissue remodeling. The treatment was reported to be well tolerated, with no device-related adverse events. These findings support parallel ultrasound as a noninvasive option for patients seeking improvement in neck and submental laxity.
Topics Covered
- Submental lifting after one ultrasound treatment
- Quantitative photographic analysis of neck laxity
- Dermal heating drives collagen tissue remodeling
- Safety of synchronous parallel ultrasound technology
The Efficacy and Safety of the High-Intensity Parallel Beam Ultrasound Device at the Depth of 1.5 mm for Skin Tightening
- Author:
- Wichai Hongcharu, MD; Kanjana Boonchoo, MD, MSc; Michael H. Gold, MD
- Publication:
- Journal of Cosmetic Dermatology - Wiley Periodicals LLC
- Date:
- May 2023
Summary
This prospective study assessed the efficacy and safety of high-intensity parallel-beam ultrasound delivered at a 1.5 mm depth for lower-face skin lifting. Thirty-six participants were evaluated using standardized digital photography and Antera 3D imaging at baseline and at one and three months after treatment. Statistically significant reductions in the mean depression volume of both nasolabial folds and marionette lines were observed at follow-up, with improvement already evident one month after treatment in more than 60% of participants. The technology is designed to stimulate neocollagenesis and neoelastinogenesis within the dermis. No adverse events were recorded. The device was clinically safe and effective for lower-face skin lifting and regeneration.
Topics Covered
- SUPERB technology targeting the mid dermis
- Lower-face skin lifting and regeneration outcomes
- Nasolabial folds and marionette line improvement
- Safety and pain after ultrasound treatment
Efficacy and Safety of High-Intensity, High-Frequency, Parallel Ultrasound Beams for Fine Lines and Wrinkles
- Author:
- Jordan V. Wang, MD, MBE, MBA; Georgina Ferzli, MD; Hana Jeon, MD; Roy G. Geronemus, MD; Arielle Kauvar, MD
- Publication:
- Dermatologic Surgery — American Society for Dermatologic Surgery / Wolters Kluwer
- Date:
- Dec 2021
Summary
A prospective, multicenter clinical study evaluated a novel high-intensity, high-frequency parallel ultrasound device for improving fine lines and wrinkles of the face and neck after a single treatment. Sixty subjects were enrolled, and 58 completed the study. At the 12-week follow-up, blinded reviewers and investigators documented meaningful clinical improvement: 86% of subjects improved on the Fitzpatrick Wrinkle and Elastosis Scale, and 88% showed investigator-rated global improvement. Most subjects also reported visible improvement and satisfaction. The treatment creates controlled thermal injury in the dermis to stimulate collagen and elastin remodeling, while cooling protects the epidermis. No device-related adverse events were reported, supporting a favorable safety profile.
Topics Covered
- Parallel ultrasound for facial wrinkle improvement
- Single-treatment face and neck regeneration outcomes
- Collagen remodeling through controlled dermal thermal injury
- Safety across diverse Fitzpatrick skin phototypes
